Chemosensory signal transduction inCaenorhabditis elegans
نویسندگان
چکیده
منابع مشابه
Cyclic nucleotides in glutamate chemosensory signal transduction of Paramecium.
Glutamate is an attractant stimulus to Paramecium tetraurelia. It causes a hyperpolarization of the cell and smooth, relatively fast swimming that is characteristic of hyperpolarizing stimuli. We show here that by 1-30 seconds of stimulation, glutamate increases intracellular cAMP. Interestingly, other attractant stimuli, such as acetate and NH4Cl, that similarly hyperpolarize the cell do not i...
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Nuclear receptors are transcription factors that often respond to small molecule metabolites and fat-soluble compounds to regulate gene expression. They broadly govern development, reproduction, metabolism, and homeostasis in diverse metazoan species and their dysregulation is associated with numerous diseases. Work in C. elegans has shed light on the seminal role of nuclear receptors in life h...
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Paramecium tetraurelia is attracted and repelled by a variety of chemical stimuli. The attractants probably signify the presence of nutrients. For attractants, there are at least three signal transduction pathways that all lead to a hyperpolarization of the cell that results in relatively fast and smooth swimming. The three pathways differ in stimuli, receptor mechanisms and second messengers. ...
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Signal transduction is a topic that pervades the current literature, and well it should, since it encompasses studies from mitogenesis to synaptic transmis sion (1,19,124), Recent years have seen pieces of many cell and physiolog ical puzzles fall into place, and the pieces repeatedly are cell surface receptors (30, 130), G proteins (12, 13,49,63,82), second messengers (3, 6, 7, 78b, 90), and...
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The metaphase to anaphase transition is a critical stage of the eukaryotic cell cycle, and, thus, it is highly regulated. Errors during this transition can lead to chromosome segregation defects and death of the organism. In genetic screens for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have identified 32 mutants in the nematode Caenorhabditis elegans in which fert...
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ژورنال
عنوان ژورنال: Genetics
سال: 2021
ISSN: 1943-2631
DOI: 10.1093/genetics/iyab004